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A total of three % of Energetic substance is excreted in urine as unchanged active substance. Tapentadol is additionally metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (two %) by CYP2D6, which are more metabolised by conjugation. Thus, Energetic compound metabolism mediated by cytochrome P450 procedure